Kenny Pickett threw for 220 yards and two touchdowns, and No. 21 Pittsburgh sacked Louisville quarterback Malik Cunningham seven occasions in a 23-20 victory on Saturday.
The Panthers moved to 3-0 for the primary time since 2014 behind a relentless protection that stored the Twenty fourth-ranked Cardinals.
Cunningham accomplished simply 9 of 21 passes for 107 yards and a landing to go together with three picks.
Patrick Jones II collected three sacks for the Panthers.
Pitt kicker Alex Kessman bounced again from three misses in opposition to the Orange to drill three discipline targets of 41 yards or extra.